2-Amino-4-tert-butylamino-6-methoxy-1,3,5-triazine → HCID 54319276, compound

HRID 2166303Notes

Reaction equation

HRID 2166303 reaction equation
[F:1][CH:2]([F:16])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10]([N:13]=[C:14]=[O:15])(=[O:12])=[O:11].[NH2:17][C:18]1[N:23]=[C:22]([NH:24][C:25]([CH3:28])([CH3:27])[CH3:26])[N:21]=[C:20]([O:29][CH3:30])[N:19]=1>O1CCOCC1>[F:16][CH:2]([F:1])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10]([NH:13][C:14]([NH:17][C:18]1[N:23]=[C:22]([NH:24][C:25]([CH3:26])([CH3:27])[CH3:28])[N:21]=[C:20]([O:29][CH3:30])[N:19]=1)=[O:15])(=[O:12])=[O:11]

Participants

4

Reactant 2

HCID 1857192-Amino-4-tert-butylamino-6-methoxy-1,3,5-triazineHCID 110969602-Difluoromethoxybenzenesulfonylisocyanate

Product 1

HCID 54319276HCID 54319276, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 5.0 g of 2-difluoromethoxyphenyl-sulfonylisocyanate and 4.0 g of 2-amino-4-tert-butylamino-6-methoxy-1,3,5-triazine is stirred in 60 ml of absolute dioxane for 3 hours at 70°-80° C. After filtration of the hot reaction mixture through active charcoal, 6.9 g of N-(2-difluoromethoxyphenyl-sulfonyl)-N'-(4-tert-butylamino-6-methoxy-1,3,5-triazin-2-yl)-urea, m.p. 213°-214° C., crystallise out on cooling of the solution.

Workup

  1. filtrationAfter filtration of the hot reaction mixture through active charcoal, 6.9 g of N-(2-difluoromethoxyphenyl-sulfonyl)-N'-(4-tert-butylamino-6-methoxy-1,3,5-triazin-2-yl)-urea, m.p. 213°-214° C.
  2. customcrystallise out
  3. temperatureon cooling of the solution

Sources & evidence

ORD record
ord-aee0cc74d61a480bafb72fb10dfbfbba
Source dataset
uspto-grants-1990_07
Patent number
US04944794

Reaction notes

Loading…