Sodium borohydride → HCID 24989422, compound

Participants

Reaction Steps

Sodium borohydride (0.23 g, 6.2 mmol) was added to a solution mixture of 2-aminocarbonylamino-6-(3-formylphenyl)indole-3-carboxamide (Compound 4-69, 1.0 g, 3.1 mmol) in anhydrous methanol and anhydrous tetrahydrofuran (methanol/tetrahydrofuran=1/1, 60 mL) under ice-cooling, and the mixture was stirred at room temperature overnight. After the reaction mixture was concentrated under reduced pressure, the precipitated solid was washed with water (30 mL), ethyl acetate (30 mL), and dried under reduced pressure to give the title compound (0.59 g) as a brown solid (yield 58%).

Provenance & Evidence