Ethanol → 2-((2-Nitro-1H-imidazol-1-yl)methoxy)-1,3-propanediol

Participants

Reaction Steps

3.01 g of 1-[2-acetoxy-1-(acetoxymethyl)ethoxy]-methyl-2-nitroimidazol (compound (1)) was dissolved in 50 ml of absolute methanol, and stirred at room temperature while being added with 5% absolute ethanol solution of sodium ethoxide dropwise until pH reached 9.0. Stirred at room temperature over 3 hours. Then Dowex 50 W (H+, made by Dow Chemical) was slowly added until the liquid had a pH of 7.0. Dowex 50 W was removed by suction filtration, and the solvent was distilled off under reduced pressure. The residue was subjected to recrystallization by ethanol to obtain 2.83 g of the title compound as light yellow needles (yield: 94%).

Provenance & Evidence