HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 5(-4-Aminophenoxy)-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 5-(4-Nitrophenoxy)-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester | HCID 13800058 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5(-4-Aminophenoxy)-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester | HCID 13800066 | — |
Reaction Steps
15 g of 5-(4-nitrophenoxy)-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester is hydrogenated in 450 ml of methanol: tetrahydrofuran=1:1 with 7.5 g of palladium on carbon (10%) at room temperature under hydrogen normal pressure. After filtering and concentrating, it is recrystallized from ethanol and 10.8 g (77% of theory) of 5-(4-aminophenoxy)-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester of a melting point of 222°-224° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04945090 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-38eb7e7c835c492295865c48e196f6c9 |
| Source note | uspto-grants-1990_07 |