反应详情

2-Iodoxybenzoic acid (1.8 g, 6.4 mmol) was added to a solution of 2-aminocarbonylamino-6-hydroxymethylindole-3-carboxamide (Compound 16-1, 1.4 g, 5.8 mmol) in dimethyl sulfoxide (100 mL), and the mixture was stirred at room temperature for 30 minutes. Water (100 mL) was added to the reaction mixture under ice-cooling, and the precipitated solid was separated by filtration. The resultant solid was washed with 0.25 N sodium hydroxide aqueous solution-(5 mL) and water (5 mL) and dried under reduced pressure to give the title compound (1.1 g) as a brown solid (yield 74%).

1. temperaturecooling
2. customthe precipitated solid was separated by filtration
3. washThe resultant solid was washed with 0.25 N sodium hydroxide aqueous solution-(5 mL) and water (5 mL)
4. customdried under reduced pressure