HCID 14405656, compound → HCID 14405658, compound

HRID 2166374Notes

Reaction equation

HRID 2166374 reaction equation
[I-].[CH3:2][N+:3]1[CH:8]=[CH:7][C:6]([C:9]([N:11]2[CH2:20][CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12]2)=[O:10])=[CH:5][CH:4]=1>[Pt]=O.CO>[CH3:2][N:3]1[CH2:4][CH2:5][CH:6]([C:9]([N:11]2[CH2:20][CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12]2)=[O:10])[CH2:7][CH2:8]1

Participants

4

Reactant 1

HCID 14405656HCID 14405656, compound

Product 1

HCID 14405658HCID 14405658, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

4 g (10.5 mmol) of 1-methyl-4-[(1,2,3,4-tetrahydro-2-isoquinolyl)carbonyl]pyridinium iodide and 0.4 g of platinum oxide are introduced into 250 ml of methanol, and the mixture is subjected to hydrogenation for 12 h under a pressure of approximately 0.41 MPa. The catalyst is filtered off, the solvent evaporated off and the residue neutralized, and an oil is obtained which crystallizes and which is used without further treatment in the following stage.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solvent evaporated off
  3. customthe residue neutralized, and an oil is obtained which
  4. customcrystallizes

Sources & evidence

ORD record
ord-8dad04b5717c4364922c72b4f510ed0b
Source dataset
uspto-grants-1990_07
Patent number
US04945096

Reaction notes

Loading…