Dimethylformamide → HCID 59189778, compound

Participants

Reaction Steps

Acetic acid (0.060 mL), thiomorpholine (0.12 mL, 1.2 mmol) and sodium cyanoborohydride (0.077 g, 1.2 mmol) were added to a solution of 2-aminocarbonylamino-6-formylindole-3-carboxamide (Compound 17-1, 0.10 g, 0.41 mmol) in anhydrous N,N-dimethylformamide (6 mL), and the mixture was stirred at room temperature overnight. Saturated sodium hydrogen carbonate aqueous solution (5 mL) and water (20 mL) were added to the reaction mixture, and the whole was extracted with ethyl acetate (30 mL). The organic layer was washed with brine (20 mL), and dried over anhydrous magnesium sulfate. After the solvent was evaporated under reduced pressure, the resultant solid was washed with chloroform (2 mL), diethyl ether (2 mL), and dried under reduced pressure to give the title compound (0.062 g) as a colorless solid (yield 45%).

Provenance & Evidence