Palmitic Acid → HCID 23039641, compound

Participants

Reaction Steps

2-Methylenepropane-1,3-diol (3.0 g) was dissolved in methylene chloride (40 ml). Dicyclohexylcarbodiimide (8.7 g), 4-dimethylaminopyridine (0.4 g) and hexadecanoic acid (8.7 g) were added. The mixture was stirred for 24 hours, filtered, and the filtrate was purified through a column of silica gel 60 (70-230 mesh, 30 g) eluting with ether/chloroform/pentane 1:1:1. The eluate was washed with saturated sodium hydrogen carbonate solution (3×70 ml), dried over anhydrous magnesium sulfate and evaporated to dryness in vacuo. Further purification was achieved by chromatography on a Waters PrepLC®/System 500A using a PrepPAK®-500/SILICA cartridge with ether/chloroform/pentane 1:1:3 as eluent.

Provenance & Evidence