HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2166432Generated: October 31, 2026
Chloroform → 1-Hexadecyloxy-3-(4-bromobutylaminocarbonyloxy)-2-methylenepropane
https://huagongshe.com/reaction/2166432
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | 3-Hexadecyloxy-2-methylenepropan-1-ol | HCID 11358886 | — |
| Reactant | 1-Bromo-4-isocyanatobutane | HCID 14971584 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-Hexadecyloxy-3-(4-bromobutylaminocarbonyloxy)-2-methylenepropane | HCID 23039605 | — |
Reaction Steps
3-Hexadecyloxy-2-methylenepropane-1-ol (from Preparation 1) (2.0 g) was dissolved in ether (40 ml). 4-Dimethylaminopyridine (0.16 g) and 4-bromobutyl isocyanate (1.6 g) were added, and the mixture was stirred for 22 hours at 22° C. Chloroform (40 ml) was added, and the mixture was purified through a column of silica gel 60 (70-230 mesh, 20 g) eluting with ether/chloroform 1:1. Further purification was achieved by chromatography on a Waters PrepLC®/System 500A using a prepPAK®-500/SILICA cartridge with ether/chloroform 1:1 as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04945098 |
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| Source dataset | uspto-grants-1990_07 |
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| ORD ID | ord-26857d8351d94a44b3a9628a154e44c4 |
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| Source note | uspto-grants-1990_07 |
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