Imidazole → HCID 23039624, compound

HRID 2166435Notes

Reaction equation

HRID 2166435 reaction equation
[CH2:1]([NH:19][C:20]([O:22][CH2:23][C:24](=[CH2:37])[CH2:25][O:26][C:27](=[O:36])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]Br)=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[NH:38]1[CH:42]=[CH:41][N:40]=[CH:39]1>C1(C)C=CC=CC=1>[CH2:1]([NH:19][C:20]([O:22][CH2:23][C:24](=[CH2:37])[CH2:25][O:26][C:27](=[O:36])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][N:38]1[CH:42]=[CH:41][N:40]=[CH:39]1)=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 23039599HCID 23039599, compound

Product 1

HCID 23039624HCID 23039624, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

1-Octadecylaminocarbonyloxy-3-(8-bromooctanoyloxy)-2-methylenepropane (from Preparation 11) (1.18 g) and imidazole (0.68 g) were stirred in toluene (20 ml) at 104° C. for 14 hours. The mixture was cooled and evaporated in vacuo. The residue was chromatographed on silica gel 60 (70-230 mesh, 40 g) with ether/chloroform/triethylamine (1:1:0.04) as eluent to give the desired product.

Workup

  1. temperatureThe mixture was cooled
  2. customevaporated in vacuo
  3. customThe residue was chromatographed on silica gel 60 (70-230 mesh, 40 g) with ether/chloroform/triethylamine (1:1:0.04) as eluent

Sources & evidence

ORD record
ord-7f6011f67e204fefb2aabad8485960fb
Source dataset
uspto-grants-1990_07
Patent number
US04945098

Reaction notes

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