6-Bromohexanoic acid → 1-Octadecylaminocarbonyloxy-3-(8-bromooctanoyloxy)-2-isopropylidenepropane

HRID 2166437Notes

Reaction equation

HRID 2166437 reaction equation
[CH2:1]([NH:19][C:20]([O:22][CH2:23][C:24](=[C:27]([CH3:29])[CH3:28])[CH2:25][OH:26])=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].BrCCCCCC(O)=O.[Br:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][C:47](O)=[O:48]>>[CH2:1]([NH:19][C:20]([O:22][CH2:23][C:24](=[C:27]([CH3:28])[CH3:29])[CH2:25][O:26][C:47](=[O:48])[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42][CH2:41][CH2:40][Br:39])=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

4

Reactant 3

HCID 202106-Bromohexanoic acidHCID 5482758-Bromooctanoic acidHCID 230396423-Octadecylaminocarbonyloxy-2-isopropylidenepropan-1-ol

Product 1

HCID 230396091-Octadecylaminocarbonyloxy-3-(8-bromooctanoyloxy)-2-isopropylidenepropane

Procedure

Following the procedure described in Preparation 9, but replacing 3-octadecylaminocarbonyloxy-2-methylenepropan-1-ol with 3-octadecylaminocarbonyloxy-2-isopropylidenepropan-1-ol (from Preparation 26) and 6-bromohexanoic acid with 8-bromooctanoic acid, the desired product was obtained.

Workup

  1. customdescribed in Preparation 9

Sources & evidence

ORD record
ord-442049124cc54d3b87f418b119c25557
Source dataset
uspto-grants-1990_07
Patent number
US04945098

Reaction notes

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