1-Isocyanatotridecane → HCID 23039655, compound

Participants

Reaction Conditions

Reaction Steps

3-(6-Bromohexanoyloxy)-2-methylenepropan-1-ol (from Preparation 44) (0.58 g), tridecyl isocyanate (0.55 g) and 4-dimethylaminopyridine (0.05 g) were mixed in methylene chloride (3 ml). After stirring for 23 hours at 22° C. the mixture was filtered, and the filtrate was purified through a column of silica gel 60 (70-230 mesh, 4 g) eluting with ether/chloroform 1:1. Further purification was achieved by chromatography on Waters PrepLC®/System 500A using a prepPAK®-500/SILICA cartridge with ether/chloroform/pentane 1:1:4 as eluent.

Provenance & Evidence