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A mixture of 3-[6-(triphenylmethoxy)hexyloxy]-2-metylenepropane-1-ol (from Preparation 46) (1.5 g) and pyridine (4.5 ml) in methylene chloride (15 ml) was cooled in an ice/water bath and octadecyloxycarbonyl chloride (1.3 g) was added. After stirring for 10 minutes at 0° C. the temperature was raised to 22° C. for 5 hours. Ether (15 ml) was added, and the mixture was filtered. The filtrate was evaporated to dryness in vacuo, and the residue was purified through a column of silica gel 60 (70-230 mesh, 15 g) eluting with ether/methylene chloride 1:1. Further purification was achieved by chromatography on Waters PrepLC®/System 500A using a prepPAK®-500/SILICA cartridge with ether/methylene chloride/pentane 1:1:3 as eluent.

1. temperaturewas cooled in an ice/water bath
2. temperaturewas raised to 22° C. for 5 hours
3. filtrationthe mixture was filtered
4. customThe filtrate was evaporated to dryness in vacuo
5. customthe residue was purified through a column of silica gel 60 (70-230 mesh, 15 g)
6. washeluting with ether/methylene chloride 1:1
7. customFurther purification