Water → HCID 23039623, compound

Participants

Reaction Steps

3-Hexadecyloxycarbonyloxy-1-[6-(triphenylmethoxy)hexyloxy]-2-methylenepropane (from Preparation 50) (1.95 g), 4-toluenesulfonic acid monohydrate (60 mg) and water (0.15 ml) were stirred in methylene chloride (30 ml) for 24 hours at 22° C. The reaction mixture was neutralized with saturated aqueous sodium hydrogencarbonate, dried over magnesium sulfate, filtered and evaporated in vacuo to dryness. Purification was achieved by chromatography on Waters PrepLC®/System 500A using a prepPAK®-500 cartridge with ether/chloroform/pentane 1:1:10 followed by ether/chloroform 1:1 as eluents.

Provenance & Evidence