Pyridine → N-(5-((2-Methylene-3-(((octadecylamino)carbonyl)oxy)propoxy)carbonyl)pentyl)pyridinium

HRID 2166448Notes

Reaction equation

HRID 2166448 reaction equation
[CH2:1]([NH:19][C:20]([O:22][CH2:23][C:24](=[CH2:35])[CH2:25][O:26][C:27](=[O:34])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][Br:33])=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[N:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[Br-:33].[CH2:1]([NH:19][C:20]([O:22][CH2:23][C:24](=[CH2:35])[CH2:25][O:26][C:27](=[O:34])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][N+:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 1049PyridineHCID 140646451-Octadecylaminocarbonyloxy-3-(6-bromohexanoyloxy)-2-methylenepropane

Product 1

HCID 194937N-(5-((2-Methylene-3-(((octadecylamino)carbonyl)oxy)propoxy)carbonyl)pentyl)pyridinium

Conditions

Temperature
60 °C

Procedure

1-Octadecylaminocarbonyloxy-3-(6-bromohexanoyloxy)-2-methylenepropane (from Preparation 9) (0.84 g) was dissolved in dry pyridine (20 ml) and heated to 60° C. for 22 hours. Excess pyridine was removed in vacuo.

Workup

  1. customExcess pyridine was removed in vacuo

Sources & evidence

ORD record
ord-87b5a3179eab4d02aa3af663963bf3dc
Source dataset
uspto-grants-1990_07
Patent number
US04945098

Reaction notes

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