Trimethylamine → 1-Octadecylaminocarbonyloxy-3-[6-(trimethylammonio)hexanoyloxy]-2-methylenepropane bromide

HRID 2166450Notes

Reaction equation

[CH2:1]([NH:19][C:20]([O:22][CH2:23][C:24](=[CH2:35])[CH2:25][O:26][C:27](=[O:34])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][Br:33])=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH3:36][N:37]([CH3:39])[CH3:38]>C(O)C>[Br-:33].[CH2:1]([NH:19][C:20]([O:22][CH2:23][C:24](=[CH2:35])[CH2:25][O:26][C:27](=[O:34])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][N+:37]([CH3:39])([CH3:38])[CH3:36])=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

Conditions

Temperature: 60 °C

Procedure

1-Octadecylaminocarbonyloxy-3-(6-bromohexanoyloxy)-2-methylenepropane (from Preparation 9) (0.84 g) was dissolved in 33% trimethylamine in ethanol (30 ml) and heated to 60° C. in a sealed flask for 5 hours. Excess trimethylamine and ethanol were removed in vacuo.

Workup

customExcess trimethylamine and ethanol were removed in vacuo

Sources & evidence

ORD record: ord-60dcf8d7720043bd8b5d5745dca2b724
Source dataset: uspto-grants-1990_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04945098

Reaction notes

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