Azobisisobutyronitrile → HCID 14365629, compound

Participants

Reaction Steps

10 g (33.8 mmol) of 9-acetyl-4-methyl-β-carboline-3carboxylic acid ethyl ester is combined in 500 ml of carbon tetrachloride with 12 g (67.4 mmol) of N-bromosuccinimide and one spatula tip of azobisisobutyronitril and heated to reflux for 1.5 hours while simultaneously exposing the reaction mixture to light. After cooling, the mixture is suctioned off from the succinimide, concentrated, and the residue is extracted by stirring with hot water and suctioned off. Yield: 10.64 g (84%) of 9-acetyl-4-bromomethyl-β-carboline-β-carboxylic acid ethyl ester, mp 188°-189° C.

Provenance & Evidence