L-Aspartic Acid → N-[(3S)-Tetrahydro-2,5-dioxo-3-furanyl]formamide

Participants

Reaction Steps

F-Asp=O is prepared by reacting L-aspartic acid with formic acid in the presence of an effective amount of acetic anhydride under conditions sufficient to form N-formyl-L-aspartic anhydride. Then an effective amount of acetic anhydride and a C3 -C6 secondary alcohol are added to the reaction mixture to consume excess formic acid. The resulting N-formyl-L-aspartic anhydride reaction mixture is suitable for further reactions without modifications.

Provenance & Evidence