Sodium hydride → Mannitol

Participants

Reaction Steps

In Method B, 3,6-anhydro-2-deoxy-4,5,7-tris-O-(phenylmethyl)-D-gluco (and D-manno) heptose mixture 4 is reacted with a tetrasubstituted bisphosphonate, where and R' and R" may be any of the aliphatic substituents listed in Table II, and sodium hydride in dimethoxy ethane, giving the isomeric mixture 2,5-anhydro-1-deoxy-1-C-(disubstituted phosphinyl)-3,4,6-tris-O-(phenylmethyl)-D-glucitol and D-mannitol 12' which are then reacted as described in Method A giving 2,5-anhydro-1-deoxy 1-(disubstituted phosphinyl)-D-mannitol, 6-(disubstituted phosphate) 14' and the corresponding D-glucitol derivative 23'. ##STR16##

Provenance & Evidence