Tributylstannane → 1-Acetyl-4-hydroxy-4-tributylstannyl-piperidine

Temperature

0 °C

Di-isopropyl amine (11.9 ml, 85 mmol) was dissolved in THF (200 ml) and cooled to 0° C. and n-butyllithium (2M, 42 ml, 85 mmol) was added over one minute. This solution was stirred at 0° C. for 15 minutes and tributyltin hydride (22.8 ml, 85 mmol) was added over one minute to give a yellow solution. After 45 minutes at 0° C. the solution was cooled to -70° C. and 1-acetyl-4-piperidone (10.2 g, 71 mmol) in THF (60 ml) was added to the solution dropwise. Upon completion of this addition, the reaction mixture had become difficult to stir and an additional 100 ml of THF was added, and stirring continued at -70° for 2.5 hours. At -70° C. the reaction was quenched by addition of sodium dihydrogen phosphate buffer, pH 6.5. The reaction was allowed to warm to 0° C. This slurry was diluted with diethylether (600 ml) and water. The organic layer was separated, washed with NaCl solution, dried over MgSO4, and evaporated to give the crude product. This was purified by flash column chromatography on silica gel using methylene chloride and 9/1 methylene chloride-ethanol. Evaporation of the appropriate fractions gave 16.4 g of the title compound, 20, which was used without further characterization.

1. customto give a yellow solution
2. temperatureAfter 45 minutes at 0° C. the solution was cooled to -70° C.
3. additionUpon completion of this addition
4. stirringto stir
5. stirringstirring
6. waitcontinued at -70° for 2.5 hours
7. customAt -70° C. the reaction was quenched by addition of sodium dihydrogen phosphate buffer, pH 6.5
8. temperatureto warm to 0° C
9. additionThis slurry was diluted with diethylether (600 ml) and water
10. customThe organic layer was separated
11. washwashed with NaCl solution
12. dry with materialdried over MgSO4
13. customevaporated
14. customto give the crude product
15. customThis was purified by flash column chromatography on silica gel
16. customEvaporation of the appropriate fractions

ORD record

ord-fa72c21bcbbf42a68ee65fc716002e4c

Source dataset

uspto-grants-1990_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04945160