Phosgene → HCID 20448947, compound

HRID 2166531Notes

Reaction equation

HRID 2166531 reaction equation
[C:1]([Cl:4])(Cl)=[O:2].[Cl:5][C:6]1[CH:7]=[C:8]([CH:10]=[CH:11][CH:12]=1)[NH2:9]>C1(C)C=CC=CC=1>[Cl:5][C:6]1[CH:7]=[C:8]([NH:9][C:1]([Cl:4])=[O:2])[CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 6371PhosgeneHCID 79323-Chloroaniline

Product 1

HCID 20448947HCID 20448947, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The intermediate is then reacted with a secondary amine in an aprotic solvent such as toluene at temperatures from room temperature or below up to the boiling point of the solvent. An example of this process is the reaction of phosgene with 3-chloroaniline to yield the intermediate N-(3-chlorophenyl)carbamyl chloride which is then reacted with dibenzylamine to yield 1,1-dibenzyl-3-(3-chlorophenyl)urea.

Sources & evidence

ORD record
ord-d5e2b737e91e478b90b861760a5c3194
Source dataset
uspto-grants-1983_06
Patent number
US04387106

Reaction notes

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