HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[(Dibenzylcarbamoyl)amino]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 4-[(dibenzylcarbamoyl)amino]benzoate | HCID 17381816 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[(Dibenzylcarbamoyl)amino]benzoic acid | HCID 20499472 | — |
Reaction Steps
A solution of 5.61 g. of 1,1-dibenzyl-3-(4-carboethoxyphenyl)urea in 100 ml of ethanol is treated with 25 ml of 1 N aqueous sodium hydroxide solution, stirred under reflux for 16 hours, allowed to cool, acidified with 1 N hydrochloric acid, and filtered. The solid is recrystallized from ethanol to yield 1,1-dibenzyl-3-(4-carboxyphenyl)urea as a white solid, mp 210°-214°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04387106 |
| Source dataset | uspto-grants-1983_06 |
| ORD ID | ord-1cbc0a9cda84493aa49faa1f0b93f3a7 |
| Source note | uspto-grants-1983_06 |