Octylamine → HCID 20206211, compound

HRID 2166553Notes

Reaction equation

HRID 2166553 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9]([CH3:18])([CH3:17])[CH2:10][CH2:11][CH2:12][C:13]([O:15]C)=O.[CH2:19]([NH2:27])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]>CCOCC>[CH2:19]([NH:27][C:13](=[O:15])[CH2:12][CH2:11][CH2:10][C:9]([C:3]1[CH:4]=[CH:5][C:6]([OH:8])=[CH:7][C:2]=1[OH:1])([CH3:18])[CH3:17])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

Participants

4

Reactant 2

HCID 8143OctylamineHCID 20206153HCID 20206153, compound

Product 1

HCID 20206211HCID 20206211, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2.5 Parts of methyl 5-(2,4-dihydroxyphenyl)-5-methylhexanoate and 5.0 parts of n-octylamine are sealed into a glass Carius tube for 3 days at 120° C. The cooled reaction mixture is taken up in ether, washed first with dilute hydrochloric acid until free of the excess oxtylamine, and then with water. After removing the ether, the residual oil, on dilution with 40°-60° C. petroleum ether containing a little ether yields 5-(2,4-dihydroxyphenyl)-5-methylhexanoic acid-n-octylamide m.p. 110°-113° C. with the following percentage composition by weight.

Workup

  1. customThe cooled reaction mixture
  2. washwashed first with dilute hydrochloric acid until free of the excess oxtylamine
  3. customAfter removing the ether

Sources & evidence

ORD record
ord-499be05c8b1840aab0deb3fe49b91aac
Source dataset
uspto-grants-1983_06
Patent number
US04387158

Reaction notes

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