Sulfuric Acid → HCID 13150876, compound

Participants

Reaction Steps

To a solution of ethyl N-phenyl-2,3-epoxysuccinamate (Compound No. 1) (0.5 g) and isopropanol (1.0 g) in benzene (30 ml), a catalystic amount of a concentrated sulfuric acid was added, the mixture was refluxed for 5 hours. The reaction mixture was washed with a saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated to dryness. The residue thus obtained was treated by silica gel column chromatography using benzene as a developer and the resulting crude crystals were recrystallized from a mixture of n-hexane-acetone to give 0.41 g of isopropyl N-phenyl-2,3-epoxysuccinamate (Compound No. 93) as colorless needles melting at 113°-114.5° C.

Provenance & Evidence