Potassium Carbonate → HCID 53687753, compound

Participants

Reaction Steps

To a mixture of 2 g (7.37 mmol) 4-methoxymorphinan-6-one (H2O was removed azeotropic) and 3 g (21.71 mmol) K2CO3 in 20 ml dry DMF was dropped at room temperature during 15 min. a solution of 900 mg (7.59 mmol) cyclobutanecarboxylic acid chloride. This mixture was stirred at room temperature for 1 h, then poured on 200 ml ice water and extracted with ether. The organic layer was extracted with 2 N HCl and brine, dried and evaporated to give an oil, which was crystallized with benzene/u/hexane to yield 2.5 g (96%) N-cyclobutylcarbonyl-4-methoxymorphinan-6-one, m.p. 125°-126°, [α]D26 -204.5° (c 0.76, CHCl3).

Provenance & Evidence