Acetic Anhydride → HCID 21603243, compound

Participants

Reaction Steps

A mixture of (-)-4-hydroxy-N-methylmorphinan-6-one (500 mg, 1.84 mmol), acetic anhydride (5 ml), and pyridine (10 ml) was stirred at room temperature overnight. Acetic anhydride and pyridine were evaporated under vacuum and the residue was taken into toluene and evaporated again. The crude product was taken into CHCl3 and washed with H2O, dried and evaporated to give a foam which was recrystallized from iPr2O-hexane to afford (301 mg, 65%). An analytical sample was recrystallized from iPr2 : mp 96°-97°; [α]D26 -46.7° (c 1.126, CHCl3).

Provenance & Evidence