HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2166753Generated: October 26, 2026
m-Chloroperbenzoic acid → N-BOC 1-amino-2-chloro-3-(p-nitrophenyl)sulfinylpropane
https://huagongshe.com/reaction/2166753
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | N-BOC 1-amino-2-chloro-3-(p-nitrophenyl)thiopropane | HCID 13135212 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-BOC 1-amino-2-chloro-3-(p-nitrophenyl)sulfinylpropane | HCID 53988848 | — |
Reaction Steps
The product from Step B, 2.II, 207 mg, in 9 ml of CH2Cl2 is treated dropwise at 0° C. over 70 minutes with 121 mg of m-chloroperbenzoic acid (MCPBA) (85%) in 9 ml of CH2Cl2 under N2. The solution is stirred 1 hour at 25° C., washed with aqueous NaHCO3, dried with MgSO4, filtered, evaporated (209 mg) and purified by preparative thin layer chromatography on silica gel with 4:1 (v/v) CHCl3 -ethylacetate, affording 97 mg of pure product, Rf 0.25.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04388475 |
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| Source dataset | uspto-grants-1983_06 |
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| ORD ID | ord-7402f6d22c854e3f8c9621e4348c0756 |
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| Source note | uspto-grants-1983_06 |
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