Thionyl Chloride → HCID 20069459, compound

HRID 2166796Notes

Reaction equation

HRID 2166796 reaction equation
[Cl:1][C:2]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[C:17]([F:25])[C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([N+:14]([O-:16])=[O:15])=[C:9]([CH:13]=1)[C:10](O)=[O:11].S(Cl)([Cl:28])=O>>[Cl:1][C:2]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[C:17]([F:25])[C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([N+:14]([O-:16])=[O:15])=[C:9]([CH:13]=1)[C:10]([Cl:28])=[O:11]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 133395815-[2-Chloro-6-fluoro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid

Product 1

HCID 20069459HCID 20069459, compound

Procedure

5-(2-Chloro-6-fluoro-4-trifluoromethylphenoxy)-2-nitrobenzoic acid (2.5 g) was heated under reflux for 5 hours with thionyl chloride (40 ml). The solution was evaporated under reduced pressure and the yellow oil remaining was taken up in toluene (100 ml). The solution was divided into four portions. Each portion was separately evaporated to give 5-(2-chloro-6-fluoro-4-trifluoromethylphenoxy)-2-nitrobenzoyl chloride as an oil. Three portions were used to prepare esters as follows:

Workup

  1. customThe solution was evaporated under reduced pressure
  2. customEach portion was separately evaporated

Sources & evidence

ORD record
ord-61cc6f672888472983300acdb12de360
Source dataset
uspto-grants-1983_06
Patent number
US04388472

Reaction notes

Loading…