Water → HCID 20497722, compound

Participants

Reaction Steps

15.8 g (0.1 mole) of 1,8-diaminonaphthalene and 16.0 g (0.1 mole) of 2,5,7-trimethyl-4-nonanone were dissolved in a mixture of 52 g of isobutanol, 24 g of water and 9 g of acetic acid and heated under reflux for 11 hours. After cooling, the solution was neutralized with 3.0 g of K2CO3. The organic layer was separated from the aqueous layer and filtered. The filtrate was evaporated in vacuo yielding a dark oily residue, which was thereafter dissolved in 2:1 hexane-diethylether and the solution filtered over alumina. After distilling off the solvent, 11.8 g of 2-isobutyl-2(2,4-dimethylpentyl)-2,3-dihydroperimidine was obtained as a semi-solid residue (Compound No. 17)

Provenance & Evidence