Ammonia → 1,4-Dihydroxy-5,8-bis[2-(2-hydroxypropylamino)ethylamino]anthracene-9,10-dione

HRID 2166816Notes

Reaction equation

HRID 2166816 reaction equation
Cl.Cl.[OH:3][C:4]1[C:17]2[C:16](=[O:18])[C:15]3[C:10](=[C:11]([NH:27][CH2:28][CH2:29][NH:30][CH2:31][CH:32]([OH:34])[CH3:33])[CH:12]=[CH:13][C:14]=3[NH:19][CH2:20][CH2:21][NH:22][CH2:23][CH:24]([OH:26])[CH3:25])[C:9](=[O:35])[C:8]=2[C:7]([OH:36])=[CH:6][CH:5]=1.N>CO>[OH:36][C:7]1[C:8]2[C:9](=[O:35])[C:10]3[C:15](=[C:14]([NH:19][CH2:20][CH2:21][NH:22][CH2:23][CH:24]([OH:26])[CH3:25])[CH:13]=[CH:12][C:11]=3[NH:27][CH2:28][CH2:29][NH:30][CH2:31][CH:32]([OH:34])[CH3:33])[C:16](=[O:18])[C:17]=2[C:4]([OH:3])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 125195511,4-Dihydroxy-5,8-bis[2-(2-hydroxypropylamino)ethylamino]anthraquinone dihydrochloride

Product 1

HCID 4330601,4-Dihydroxy-5,8-bis[2-(2-hydroxypropylamino)ethylamino]anthracene-9,10-dione

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 6.0 g of 1,4-dihydroxy-5,8-bis[2-(2-hydroxypropylamino)ethylamino]anthraquinone dihydrochloride (prepared according to the procedure given in Example 32 of U.S. Pat. No. 4,197,249) and 60 ml of methanol may be treated with ammonia gas under the procedure of Example 1 to give the corresponding free base 201, 1,4-dihydroxy-5,8-bis[2-(2-hydroxypropylamino)ethylamino]-anthraquinone.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-8a092aa97f704675877a2406345ac173
Source dataset
uspto-grants-1983_06
Patent number
US04389399

Reaction notes

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