Diethyl Ether → HCID 70531060, compound

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Reaction Steps

1-(α-Hydroxy-2,4-dichlorophenethyl)imidazole, 12.85 g (0.05 mole), was dissolved in 100 ml chloroform and 8.33 g (0.07 mole) thionyl chloride was added to cause immediate formation of a solid precipitate. The mixture was refluxed three hours causing total solution of all solids. No precipitate formed on cooling to ambient temperature. A solid precipitate formed on pouring the chloroform solution into 500 ml of ether. The solid was collected and dried, 8.67 g (55.6%), m.p. 165°-167° C. Both ir and H1 nmr spectra supported the chemical structure. DMSO δ TMS 7.4 (m, 6H, aryl/imidazole); 5.78 (t, 1H, CH); 4.1 (d,2H, CH2).

Provenance & Evidence