p-Toluenesulfonic acid → HCID 13150727, compound

Participants

Reaction Steps

A mixture of 600 mg of the norpinene compound (prepared in Reference Example 2), 0.5 ml of 2,3-dihydropyran, a catalytic amount of p-toluenesulfonic acid and 10 ml of methylene chloride was stirred at room temperature for 30 minutes. 0.2 ml of triethylamine was added to the reaction mixture, followed by concentration under reduced pressure. The residue was purified by silica gel column chromatography using a mixture of cyclohexane and ethyl acetate (49:1) as an eluent to obtain 812 mg of the titled compound.

Provenance & Evidence