Dimethylformamide → HCID 67369495, compound

Participants

Reaction Steps

In an ice bath, 7.8 g of 15α-hydroxy-18-methyl-4-estren-17-one in 50 ml of pyridine is combined with 10 ml of methanesulfonic acid chloride. After 1 hour, 50 ml of dimethylformamide (DMF) is added thereto, along with 23 g of anhydrous sodium acetate. The mixture is stirred for another 20 hours at room temperature. The mixture is introduced into ice/water. The thus-precipitated product is vacuum-filtered, washed with water, dissolved in ethyl acetate, and dried. Crystallization from ethyl acetate yields 5.1 g of 18-methyl-4,15-estradien-17-one, mp 125.2° C.

Provenance & Evidence