Hydrochloric Acid → HCID 20497320, compound

Participants

Reaction Steps

205 g (0.4 mol) of 1-hydroxy-4-ethoxycarbonylmethyloxy-N-(3-n-dodecyloxypropyl)2-naphthamide was dispersed in 600 ml of methanol at the room temperature. A solution containing 105 g of potassium hydroxide in 250 ml of methanol was added slowly with stirring, followed by stirring for 1 hour. After being neutralized by adding concentrated hydrochloric acid, the precipitated crystals were filtered off and dried to obtain 184 g (94% yield) of 1-hydroxy-4-carboxymethyloxy-N-(3-n-dodecyloxypropyl)2-naphthamide. Melting point: 150° C.

Provenance & Evidence