p-Toluenesulfonic acid → HCID 70531396, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 10 g of ethyl 4-(4-aminobutyl)-piperazine-1-carboxylate, 5 g of 3-amino-2-hydrazino-6-methylquinazolin-4-(3H)-one and 0.5 g of p-toluenesulfonic acid was heated to 180° C. (bath temperature of reaction mixture 160° C.) for 4 hours. After cooling to 100° C., the reaction mixture was dissolved in 250 ml of toluene and was washed twice with 100 ml of water. The mixture filtered through `celite` and the product was retained in the toluene solution for use in the next stage.

Provenance & Evidence