Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Fluoride | HCID 5235 | — |
| Reactant | Fluorine | HCID 24524 | — |
| Reactant | Ethyl 2-oxo-3-phenylpropanoate | HCID 12292599 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | 1,1,1-Trichloro-2,2,2-trifluoroethane | HCID 9635 | — |
| Product | HCID 11095876 | HCID 11095876 | 40% |
Reaction Steps
Ethyl 3-phenylpyruvate (10 g; 0.052 mol) is dissolved in a mixture of acetonitrile (60 g) and trichlorotrifluoroethane (410 g), and the resulting solution is cooled to -10° C. Then, fluorine gas (0.067 mol) diluted with nitrogen to 10% concentration is introduced therein over a period of 2.5 hours while stirring vigorously. After addition of sodium fluoride (2 g), the solvent is distilled off under reduced pressure, and the residue is rectified to give ethyl 3-phenyl-3-fluoropyruvate (4.37 g). Boiling point, 90°-95° C./1 mmHg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04390702 |
|---|
| Source dataset | uspto-grants-1983_06 |
|---|
| ORD ID | ord-54f5c8e78f0d4be5a61589bfd83f751e |
|---|
| Source note | uspto-grants-1983_06 |
|---|
