Fluorine → HCID 12886212, compound

HRID 2166933Notes

Reaction equation

HRID 2166933 reaction equation
[C:1]([CH2:6][C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])(=[O:5])[CH2:2][CH2:3][CH3:4].[F:14]F>C(#N)C>[C:1]([CH:6]([F:14])[C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])(=[O:5])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 24524FluorineHCID 3006750Ethyl 2,4-dioxoheptanoate

Product 1

HCID 12886212HCID 12886212, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In the same manner as in Example 1, ethyl 3-butyrylpyruvate (9.53 g; 0.0512 mol) is dissolved in acetonitrile (94 g) and reacted with fluorine at -5° C. By distilling off the solvent under reduced pressure, there is obtained a crude product (5.5 g), which is rectified to give ethyl 3-butyryl-3-fluoropyruvate. Boiling point, 72°-78° C./2 mmHg.

Workup

  1. distillationBy distilling off the solvent under reduced pressure
  2. customthere is obtained a crude product (5.5 g), which

Sources & evidence

ORD record
ord-d54204b361c843aeaf5cc553d138abd4
Source dataset
uspto-grants-1983_06
Patent number
US04390702

Reaction notes

Loading…