Fluorine → HCID 10487006, compound

HRID 2166935Notes

Reaction equation

HRID 2166935 reaction equation
[CH3:1][CH2:2][C:3](=[O:9])[C:4]([O:6][CH2:7][CH3:8])=[O:5].[F:10]F>C(#N)C>[CH3:1][CH:2]([F:10])[C:3](=[O:9])[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 24524FluorineHCID 85195ethyl acetoacetate, sodium salt

Product 1

HCID 10487006HCID 10487006, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In the same manner as in Example 1, ethyl 3-methylpyruvate (1.0 g; 8.62 mmol) is dissolved in acetonitrile (22.5 g) and reacted with fluorine. By distilling off the solvent under reduced pressure, there is obtained a crude product, which is rectified to give ethyl 3-methyl-3-fluoropyruvate.

Workup

  1. distillationBy distilling off the solvent under reduced pressure
  2. customthere is obtained a crude product, which

Sources & evidence

ORD record
ord-274dcba42237467385d07c5696ec563c
Source dataset
uspto-grants-1983_06
Patent number
US04390702

Reaction notes

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