Trifluoroacetic acid → HCID 131712115, compound

Participants

Reaction Steps

To a solution of 147 mg of benzhydryl 3-(2-pyrazinylvinyl)-7β-(2-thienylacetamido)-3-cephem-4-carboxylate in 1.5 ml anisole at 0° was added 3 ml of cold trifluoroacetic acid. The solution was kept 10 minutes at 0° and then placed directly on a vacuum pump and evaporated. The residue was flushed with 1 ml anisole and reevaporated. The residue was triturated with 4 ml boiling ether and the ether was cooled and siphoned off. The procedure was repeated twice more. The remaining insoluble material weighed 116 mg yield 87% (calculated as mono-CF3COOH salt) and was characterized by n.m.r. and electrophoresis.

Provenance & Evidence