HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2166988Generated: November 1, 2026
Hydrochloric Acid → 7-Hydroxy-4-oxo-4H-chromen-2-carboxylic acid
https://huagongshe.com/reaction/2166988
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | ethyl 7-hydroxy-4-oxo-4H-chromen-2-carboxylate | HCID 5376802 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-Hydroxy-4-oxo-4H-chromen-2-carboxylic acid | HCID 5479463 | — |
Reaction Steps
2-Ethoxycarbonyl-7-hydroxychromone (14.5 g, 62 mmol) is initially introduced dissolved in ethanol (400 ml) at 50° C., and sodium carbonate (20 g, 190 mmol) dissolved in deionised H2O (200 ml) is added dropwise. The mixture is refluxed at 80° C. for 3 hours with stirring. After cooling, the mixture is acidified using 2N HCl. The precipitated white solid is filtered off with suction, washed until neutral and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09044409B2 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-2105b31fe3814926b63ea94b93e0d9f5 |
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| Source note | uspto-grants-2015_06 |
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