HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → Apomorphine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Mannitol | HCID 6251 | — |
| Reactant | 4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride (1:1), (6aR)- | HCID 9410 | — |
| Solvent | Water | HCID 962 | — |
| Product | Apomorphine | HCID 6005 | — |
Reaction Steps
Gelatin and mannitol are dispersed in purified water and mixed thoroughly (i.e., using a vacuum mixer) and homogenized. Apomorphine hydrochloride is added and the mixture was again homogenized to ensure complete dissolution of the apomorphine hydrochloride. The pH of the solution is adjusted to about 3.0 (i.e., by addition of a suitable acid, such as citric acid). The solution is then poured onto a sheet and dried in a heated oven.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09044475B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-209d9e9339364d4db7de1f3c96ee0a96 |
| Source note | uspto-grants-2015_06 |