反应详情

A solution of 1.17 g (5 mmol) (4-Bromo-phenyl)-acetyl chloride (CAS 37859-24-8) in 25 ml CH2Cl2 is added dropwise to a solution of 710 mg (5.25 mmol) thiomorpholine 1,1-dioxide in 25 ml CH2Cl2. After complete addition, the reaction mixture is partitioned between water and CH2Cl2. The aqueous phase is re-extracted twice with CH2Cl2. The combined organic solution is washed with brine, dried over Na2SO4 and concentrated in vacuo to afford the title compound as a light yellow residue.

1. additionAfter complete addition
2. customthe reaction mixture is partitioned between water and CH2Cl2
3. extractionThe aqueous phase is re-extracted twice with CH2Cl2
4. washThe combined organic solution is washed with brine
5. dry with materialdried over Na2SO4
6. concentrationconcentrated in vacuo