HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (3-[4(3-Diisobutylamino-propyl)-piperazin-1-yl]-propyl}-3-(4-methyl-2-nitro-phenyl)-thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Methyl-2-nitrophenyl isothiocyanate | HCID 140258 | — |
| Reactant | Ezeprogind | HCID 10252009 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (3-[4(3-Diisobutylamino-propyl)-piperazin-1-yl]-propyl}-3-(4-methyl-2-nitro-phenyl)-thiourea | HCID 87388693 | — |
Reaction Steps
A solution of N4-(3-{4-[3-(diisobutylamino)propyl]piperizano}propyl)-amine (intermediate of example 16) (103 mg, 0.33 mmol) and 4-methyl-2-nitrophenyl isothiocyanate (128 mg, 0.66 mmol) in CH2Cl2 (10 mL) has been stirred for 4 h at room temperature. NaOH 1M is added until alkaline pH. Organic layer was washed with NaOH 0.5M and dried over MgSO4. Crude compound is purified by thick-layer chromatography (CH2Cl2/MeOH: 90/10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09044478B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-b55f8357388342149cd4131ce6895693 |
| Source note | uspto-grants-2015_06 |