HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-{3-[4-(3-Diisobutylamino-propyl)-piperazin-1-yl]-propyl}-3-(4-methoxy-2-nitro-phenyl)-thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Methoxy-2-nitrophenyl isothiocyanate | HCID 141006 | — |
| Reactant | Ezeprogind | HCID 10252009 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-{3-[4-(3-Diisobutylamino-propyl)-piperazin-1-yl]-propyl}-3-(4-methoxy-2-nitro-phenyl)-thiourea | HCID 87388799 | — |
Reaction Steps
A solution of N4-(3-{4-[3-(diisobutylamino)propyl]piperizano}propyl)-amine (intermediate of example 16) (103 mg, 0.33 mmol) and 4-methoxy-2-nitrophenyl isothiocyanate (139 mg, 0.66 mmol) in CH2Cl2 (10 mL) has been stirred for 4 h at room temperature. NaOH 1M is added until alkaline pH. Organic layer was washed with NaOH 0.5M and dried over MgSO4. Crude compound is purified by thick-layer chromatography (CH2Cl2/MeOH: 90/10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09044478B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-484929fec2164bb4b63e425b1e006229 |
| Source note | uspto-grants-2015_06 |