Trifluoroacetic acid → HCID 131732900, compound

Participants

Reaction Steps

To a solution of N-Boc-Dap-2-AQ (11, 68.0 mg, 0.16 mmol) in CH2Cl2 (4 mL) that was stirring at 0° C. under argon was added trifluoroacetic acid (TFA, 2 mL), and stirring was continued for 2 h with warming to rt. The solvent was removed under vacuum, toluene being used to form an azeotrope with the remaining TFA. The residue, a yellow oil, was allowed to stand under diethyl ether for 1 h. Removal of the ether left a yellowish oily solid to which hexane was added and removed under vacuum until a constant weight was reached (99.4 mg; quantitative), and this material was used immediately in the next reaction.

Provenance & Evidence