3-Hydroxybenzyl alcohol → (3-Isopropoxyphenyl)methanol

Participants

Reaction Conditions

Reaction Steps

To a mixture of 3-(hydroxymethyl)phenol (10 g) and potassium carbonate (27.2 g) in DMF (100 ml) was added 2-bromo-propane (14.8 g), the reaction was heated to 90° C. overnight. The reaction mixture was filtered and the filtrate was concentrated and purified by chromatography on silica gel, eluting with petrol:ethyl acetate=5:1.

Provenance & Evidence