HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → 2-Bromo-1-(bromomethyl)-4-(trifluoromethyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-Bromo-1-methyl-4-(trifluoromethyl)benzene | HCID 2779376 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Bromo-1-(bromomethyl)-4-(trifluoromethyl)benzene | HCID 14949936 | — |
Reaction Steps
Solid benzoyl peroxide (1.5 g, 6.3 mmol) was added to a benzene solution (200 mL) of 2-bromo-1-methyl-4-(trifluoromethyl)benzene (10.0 g, 41.8 mmol) and NBS (8.2 g, 46.0 mmol) and the resulting mixture was refluxed. After 16 h the resulting mixture was cooled, diluted with EtOAc, washed with water and brine, dried (Na2SO4), and dry packed onto silica gel. Column chromatography yielded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045389B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-0d199021d8924a9c972e133f47df041a |
| Source note | uspto-grants-2015_06 |