Tetrahydrofuran → HCID 86674208, compound

Participants

Reaction Steps

A 3M aqueous solution of NaOH (3.9 mL, 11.8 mmol) was added to a THF (10 mL) and MeOH (5 mL) solution of methyl 2′-formyl-5′-(trifluoromethyl)-[1,1′-biphenyl]-4-carboxylate (1.2 g, 3.9 mmol) and the resulting homogeneous mixture was stirred at room temperature. After 16 h the resulting mixture was concentrated in vacuo, suspended in water, and acidified with 2 M HCl. The resulting precipitate was filtered off, dried in vacuo, and purified via HPLC to yield the title compound.

Provenance & Evidence