HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromobenzoic acid → HCID 71059874, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromobenzoic acid | HCID 11464 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | Tert-butyl 3-aminopropanoate hydrochloride | HCID 16218890 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 71059874 | HCID 71059874 | — |
Reaction Steps
Solid HATU (4.5 g, 11.9 mmol) was added to a DMF solution (5 mL) of 4-bromobenzoic acid (2.0 g, 9.9 mmol), i-Pr2Net (5.3 mL, 14.0 mmol), and β-alanine tert-butyl ester hydrochloride (1.8 g, 9.9 mmol) and the resulting mixture was stirred at room temperature. After 3 days the resulting mixture was concentrated, diluted with EtOAc, washed with water, 1N KHSO4, water, saturated aqueous NaHCO3, and brine. The organic layer was dried (Na2SO4), concentrated to yield the title compound that was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045389B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-bce5cb69b13e41c3bc9087263ecdb87b |
| Source note | uspto-grants-2015_06 |