Potassium Phosphate, Tribasic → HCID 86674213, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Phosphate, Tribasic	HCID 62657	—
Reactant	4-Methoxycarbonylphenylboronic acid	HCID 2734369	—
Reactant	2,6-Dichloro-4-(trifluoromethyl)benzaldehyde	HCID 14793914	—
Catalyst	Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)	HCID 178418228	—
Solvent	Water	HCID 962	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 86674213	HCID 86674213	—

Reaction Conditions

Temperature	90 °C

Reaction Steps

2,6-Dichloro-4-(trifluoromethyl)benzaldehyde (406 mg, 1.7 mmol), (4-(methoxycarbonyl)phenyl)boronic acid (150 mg, 0.8 mmol), Pd(dppf)Cl2 (81 mg, 0.1 mmol) and K3PO4 (769 mg, 3.3 mmol) were dissolved in wet 1,4-dioxane (20 mL) and the resulting mixture was heated to 90° C. After 10 h the resulting mixture was diluted with water and extracted with EtOAc. The combined organic extracts were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09045389B2
Source dataset	uspto-grants-2015_06
ORD ID	ord-1b16dc9286ea4115b5dcf2eeffa3ee3f
Source note	uspto-grants-2015_06